From the side of hematopoiesis: Reported rarely thrombotic microangiopathy. In such cases, it recommended to temporarily stop receiving sunitinib; after the resolution of symptoms of the drug may be renewed at the discretion buy winstrol of the attending physician. From the side of respiratory system: Cases of pulmonary embolism, sometimes with fatal outcome.
Endocrine system: In clinical studies and in the rare cases of hyperthyroidism were reported during post-marketing use of the drug with transition to hypothyroidism. immune system: reported hypersensitivity reactions, including angioedema. infections and infestations: cases of serious infection (against a background of neutropenia with or without), some of which were fatal. on the part of the musculoskeletal system:available reports of rare cases of myopathy and / or rhabdomyolysis with or without combination with acute renal failure, with rare cases of death. The majority of these patients had underlying risk factors and / or they were receiving concomitant therapy with drugs, which are peculiar to undesirable reactions of this kind. there have been reports of cases of fistula formation, sometimes associated with necrosis and / or regression of tumors, some of which were fatal. from the nervous system: there are reports of taste sensitivity disorders, including ageusia. from buy winstrol the urinary system: there have been reports of violations . renal / kidney failure, some of which were fatal have been reported cases of proteinuria and rare cases of nephrotic syndrome. Since the cardiovascular system: reported cases of cardiomyopathy, some of which were fatal.
specific antidote does not exist. In case of overdose symptomatic treatment. If necessary, it is recommended to induce vomiting or gastric lavage hold.
The interaction with other drugs . The drugs that increase the concentration of sunitinib in plasma. The combined use of a single dose of sunitinib with an inhibitor of isozyme , ketoconazole enhances sunitinib and the main active metabolite of healthy volunteers by 49% and 51%, respectively. Use of the together with other inhibitors isoenzyme (for example, ritonavir, itraconazole, erythromycin, clarithromycin or grapefruit juice) may increase sunitinib concentration. Coadministration isoenzyme inhibitors should be avoided or select an alternative drug with minimal ability to inhibition of isoenzyme. If this is not possible, it is likely to be necessary to reduce the daily dose of sunitinib 12.5 mg. In this case, the daily dose should not be less than 37.5 mg. Drugs that decrease in the plasma concentration of sunitinib.
The combined use of a single dose of sunitinib with inductor isoenzyme, rifampicin, and reduces , in healthy volunteers and 23% 46%, respectively. Use of in conjunction with other inducers (eg, dexamethasone, phenytoin, karbmazepinom, rifampicin, phenobarbital or Hypericum perforatum) may lead to a decrease sunitinib concentrations. avoid co-administration of inducers with or should choose an alternative drug with a minimum capacity kinduktsii isoenzyme buy winstrol. If this is not possible, it is likely to be necessary to increase the dose of sunitinib 12.5 mg, controlling the patient tolerated the drug. The daily dose in this case should not exceed 87.5 mg.
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